An introduction to choosing the B.E.S.T. extraction process for your business.

In this video segment, Dr. MacKay provides an overview of the B.E.S.T. concentration processes for natural products. This breakdown includes maintaining the integrity of botanical materials, effective concentration with efficacy, efficiency, and economics, safety and health for everyone throughout the process. He also covers testing with modern technology advances in every facet.

In this video segment, Dr. MacKay discusses the key compounds in cannabis. This includes the amount of cannabinoids dependent on the variety and quality of raw material, as well as how sample preparation is key to the extraction and quality of results. Finally, how the instrument conditions affect the yield, quality, and components is discussed.

In this video segment, Dr. MacKay discusses sticking to the best concentration process for natural products, as well as the synergistic merging of science and economics for the extraction of cannabis products. Finally, he talks about how the challenges with cannabis extraction are often overlooked and underestimated, including a discussion about Sutton's Law and banking protocol.

In this video segment, Dr. MacKay describes the three main types of trichomes in the cannabis plant. He begins with bulbous trichomes as the smallest of the three types being found across the base of the plant. Next, you will learn about capitate-sessile trichomes as the next largest group, and why it is significantly more abundant. Finally, capitate-stalked trichomes are formed after the flowering stage, and where most cannabinoids are commonly found.

In this video segment, Dr. MacKay talks about how cannabinoids get into the capitate stalk, as well as the importance of understanding how biosynthesis provides secrets to biopharma technology. Finally, piecing the capitate-stalked glands for finding where cannabinoids are synthesized and stored in cannabis are discussed.

In this video segment, Dr. MacKay describes the concentration techniques of extraction and separation and their applications in the cannabis industry. This includes a detailed review of separation as a mechanical process without solvent, as well as the process of extraction with a solvent. Further concepts discussed include maceration and grinding, chromatography, filtration, and the representative solvents commonly used in extraction.

In this video segment, Dr. MacKay talks about the key parameters of process control and optimization. This includes the critical parameters of C02 for process control such as thermodynamics, pressure, temperature, mass transfer, and flow rate. Finally, the conditions of maximizing productivity and profitability are discussed.

In this video segment, Dr. MacKay examines the generalized extraction process from a single cell with different concentrations and conditions. Next, the generalized extraction process inside a vessel is discussed. This includes the solubilization of compounds to be extracted, and the rate of transport for the extracted compounds.

In this video segment, Dr. MacKay discusses cannabis extraction for the Partition Coefficient and Log P. Dr. MacKay performs an extraction experiment for Partition Coefficient and Log P. This experiment highlights the solubility of various solvents, as well as the non-polar properties of cannabinoids.

In this video segment, Dr. MacKay talks about three major extraction kinetics, which are mechanically dominant, pressure dominant, and solubility dominant. Next, he discusses the process of how we move into a cell, and how the solvent moves in and binds the "A and B" cell wall before it then moves outside. Finally, Dr. MacKay shares an analogy of a dog to describe the process.

In this video segment, Dr. MacKay describes the advances in separation, extraction, and concentration techniques and their applications in the cannabis industry. This includes a detailed review of separation as a mechanical process without solvent, as well as the concepts of maceration and grinding, parts of chromatography, and filtration.

In this video segment, Dr. MacKay provides an overview of the B.E.S.T. concentration processes for natural products. This breakdown includes maintaining the integrity of botanical materials, effective concentration with efficacy, efficiency, and economics, safety and health for everyone throughout the process. He also covers testing with modern technology advances in every facet.

In this video segment, Dr. MacKay discusses key factors to consider in choosing concentration technology. First, he examines the speed and cycle time of the concentration process. Next, he examines scale and the ability to start small and then grow the entire concentration process. Finally, he discusses selectivity and influencing the order of elution in the entire concentration process.

In this video segment, Dr. MacKay talks about why few large facilities exist for cannabis. This discussion includes economies of scale, large-scale system limitations with the variety of plants, formulation-centric starting materials and equipment size, as well as the regulation of solvents and processes that are allowed. Finally, site sophistication and protocol within state regulations are discussed.

An introduction to essential cannabis extraction principles.

In this video segment, Dr. MacKay describes the three main types of trichomes in the cannabis plant. He begins with bulbous trichomes as the smallest of the three types being found across the base of the plant. Next, you will learn about capitate-sessile trichomes as the next largest group, and why they are significantly more abundant. Finally, capitate-stalked trichomes are formed after the flowering stage, and most commonly found in the buds and leaves of cannabis plants.

In this video segment, Dr. MacKay describes the process of maximizing separation in order to scale. Next, the process of using both C02 and ethanol to maximize separation in order to scale during the cannabis extraction process is discussed.

In this video segment, Dr. MacKay describes the process of scaling from analytical to bulk, as well as the study of the contribution of SFF parameters including preparation of feedstock, extractor conditions, and separator conditions. Finally, the design of experiment and conditions including pressure, temperature, solvent, and superficial velocity is discussed.

In this video segment, Dr. MacKay describes applying the design of the experiment, and the generalized extraction process inside a vessel. Next, he examines the factor of speed and cycle time of the concentration process, as well as the factor of scale and the ability to start small and grow the entire concentration process. Finally, the factor of selectivity and influencing the order of elution in the entire concentration process is discussed.

In this video segment, Dr. MacKay describes examples of applying the design of the experiment. Next, he examines decarboxylation at different temperatures, the solubility of four cannabinoids in supercritical CO2, experimental design, and maximizing cannabis extraction using the B.E.S.T. concentration process for natural products.

In this video segment, Ben Stephens gives an introduction to the principle and practice of alcohol dominant extraction. He describes why ethanol is one of the most common solvents used over the centuries.

In this video segment, Ben Stephens explains why ethanol is one of the most common solvents used over the centuries. Ethanol is an extremely versatile solvent and is applicable in many applications. Coupling this with how easy it is to manufacture, and how long it has been manufactured, it has made it the ideal candidate throughout the years for various botanical extractions.

In this video segment, Ben Stephens talks about the principles of successful extraction with ethanol. Understanding your inputs, and furthermore controlling them as much as possible, is an integral piece to any extraction process. This can and should include knowing the farms and farmers where your biomass comes from, but it should also include how you process and store your biomass prior to extraction. The main considerations here are ensuring the biomass has been properly and thoroughly cured and dried, is subsequently stored in a temperature controlled and dry environment, and also is consistently milled.

In this video segment, Ben Stephens touches on controlling extraction parameters. Temperature and residency time are the most important variables during ethanol extraction. Changing and maintaining the temperature of your solvent during extraction is vital because it changes what compounds your ethanol will target and how fast (dictating your optimal residency time) it will dissolve them.

In this video segment, Ben Stephens addresses the problems pertaining to ethanol. One of the biggest challenges faced by ethanol processors who intend to operate at a large scale is solvent recovery. Ethanol is an enormously efficient solvent, and will allow you to process more biomass than perhaps any other methods currently on the market, if you have the ability to evaporate and recover that amount of solvent at scale.

In this video segment, Ben Stephens goes in depth on the entire process of full ethanol processing. Understanding and controlling your inputs are vital pieces of any extraction process. Perhaps the most vital piece is understanding how your biomass was grown and how it was handled prior to your lab. For large scale producers who are mostly aiming to produce distillate or isolate, there is a golden ratio between what their biomass costs by weight, and how potent or how much cannabinoids are present in it. For them, purchasing trim is usually the best option because it is cheaper than buds and flowers but still has adequate quantities of their desired compounds.

In this video segment, Ben Stephens dives into plant processing. In any industrial processing setting, especially at scale, the main goal is to minimize variables to create the most consistent product desired. We’ve already briefly touched on some of the most important, such as temperature and biomass preparation. When it comes to ethanol, the ability to dissolve both polar and non-polar compounds from the plant comes with a set of benefits as well as a set of complications. One of the potential complications with cannabis processing is that the main target compounds are primarily non-polar. Under certain circumstances ethanol can pick up some undesirable compounds that are polar, causing more processing steps.

In this video segment, Ben Stephens breaks down developing a financial model for ethanol extraction. There is always a golden ratio for processors between the price and potency of their inputs. This is why it is advantageous when processing at a large scale and with specific end products (isolate, distillate) in mind to do a cost analysis on the price per mg of active compounds (CBD or THC for example) in your inputs. Although their inputs, especially when their end product requires high contents of terpenes, are on average much more expensive, so are their retail prices for their end products.

In this video segment, Eric Kawka gives an introduction to extraction regarding sub- and supercritical fluids. Eric's background is in supercritical fluid extraction and supercritical fluid chromatography.

In this video segment, Eric Kawka talks about appreciating the complexity of cannabis sativa. Within cannabis there are two compounds that are vital, terpenes and cannabinoids. There are more than 80 different cannabinoids. Both terpenes and cannabinoids interact with our endocannabinoid system with over 300 hundred receptors.

In this video segment, Eric Kawka shows how extracting cannabis is similar to brewing a cup of coffee. Two compounds of similar properties with respect to polarity will be soluble together. Water, which is polar, and oil, which is non-polar, will not mix together. But like coffee, cannabis must start with the proper cultivar.

In this video segment, Eric Kawka looks into the key parameters for process control. Thermodynamics is one of the critical parameters that pertains to pressure and temperature.

In this video segment, Eric Kawka answers the question, is supercritical CO2 just a marketing term? A supercritical fluid is a fluid brought to a temperature and pressure higher than its critical point, where physical and chemical properties change.

In this video segment, Eric Kawka covers how terpenes and cannabinoids are synthesized and stored in trichomes. Trichomes dictate what the end product is with extraction. In the SC-CO2 efficiency curve, there are two sections that dictate things, the mechanical region and the diffusion limited region.

In this video segment, Eric Kawka dissects the molecular structure of cannabinoids. Terpenes and cannabinoids create an entourage effect, while myrcene has an analgesic effect. Terpenes also go through isomerization, oxidation, dehydration, polymerization, and thermal rearrangements.

An introduction to advanced extraction with sub- and supercritical fluids

This video discusses carbon dioxide (CO2) and how it can be utilized in solventless extraction. In addition, the video depicts several diagrams and charts that show the distinct phases of CO2 during the extraction process.

This video discusses the relationship of pressure and temperature with regard to carbon dioxide (CO2). In addition, the video shows several visual aids that portray how you can create different compounds when using CO2 during extraction.

This video discusses how to optimize your extraction strategy when using CO2. In order to optimize this process, extractors should aim for a 90% recovery rate, understand the final product, and be able to make economic decisions while extracting.

This video discusses unity operations that are required as a part of solventless extraction. In addition, the video provides details on several steps such as drying, milling, pre-process, extraction, winterization, and distillation.

This video provides helpful tips and tricks when it comes to the complicated and highly technical field of cannabis extraction. In addition, the video details the pretreatment of material, drying, milling, homogenization, bed compaction, fractionation, and much more.

This video discusses the fractionation of cannabis material. In addition, it discusses how to create a scalable strategy for fractionation, necessary extraction equipment, collecting cannabinoids and terpenes, cyclone separators, and much more.

This video discusses ways extractors can increase their process productivity and improve the quality of the final product. In order to do so, it’s recommended to use online tools, research extraction studies, and utilize pilot scale systems.

This video discusses the post-processing of raw oil and highlights the steps of winterization, filtration, solvent removal, decarboxylation, decolorization, THC remediation, and more.

This video provides a real-world example of THC remediation. It also portrays the important role that analytics can play within the extraction process.

This video discusses how you can develop a financial model for your extraction facility. In addition, it discusses scaling equipment, extraction method, ROI models, biomass material, hardware, costs, post-processing, analytics, and much more.

An introduction to solventless solutions.

This video provides an overview of two popular concentrates: hash and rosin. In addition, it details the necessary extraction process and common delivery methods.

This video discusses what to keep in mind when building a solventless separation facility. Main concerns that must be addressed include sterility, climate control, ventilation, work flow, drainage, occupational protection, proper equipment, waste solvent disposal, and GMP Standards.

This video provides a step-by-step guide that explains how to make hash. In addition, it provides tips such as not over saturating the wash vessel, using appropriate equipment, maintaining temperature controls, and suggested agitation time periods.

This video offers a comparison between air drying and freeze drying. It also lists the pros and cons of each method so viewers can decide which option best fits their extraction operation.

This video discusses the economic advantages and inefficiencies that are inherent in solventless extraction. It also touches on rosin, hash, pricing, yield, and recovery rates.

This video offers a quick overview of dry sieving or sifting, which many cannabis consumers are probably already familiar with. In addition the video discusses topics such as kief, terpenes, trichomes, temperature controls, cost, rosin pressing, and scalability.

This video provides an in-depth explanation of how to make rosin through solventless extraction methods. It offers tips and tricks throughout the extraction process and also touches on topics such as sifting, productivity, labor costs, temperature controls, necessary equipment, THCA, and Rosin Sauce.

In this video segment, Amber Wise gives an introduction to environmental and contamination impact. Topics include the motivation for using data, units of measurement, analytical examples and the general cost to do them with an extraction, and ways the data can be used.

In this video segment, Amber Wise gives insight on the motivation of using data. What is the motivation to use using data at all? It is important to know that no extraction process will be 100 percent efficient. One of the first steps is to quantify your starting materials.

In this video segment, Amber Wise talks about what kind of samples to take and when in the process to take them. Raffinate is a waste material that is left in the extractor. The ethanol/water azeotrope is very hard to separate, and when ethanol absorbs water it affects the ethanol. It is vital to ensure your hygrometer is calibrated so obtain accurate results.

In this video segment, Amber Wise covers the units of measurement pertaining to extraction. You will need to convert measurements to maintain accurate analytics, such as always converting to grams. It is also important to count the molecules for accurate measurements and to know when to use mole units. Yield and mass balance calculations take into account the entire process.

In this video segment, Amber Wise goes in-depth on different types of analytics and their general costs. It is always hard to get good, quick data inexpensively. The least expensive way is thin-layer chromatography or TLC. For cannabinoid testing, high performance liquid chromatography is good for accuracy with flowers and pre-extraction material. The most expensive testing is liquid chromatography-mass spectrometry.

In this video segment, Amber Wise gives examples on how data can be used. She advises walking through the mass balance, converting everything to moles, and adding up all the losses. She also discusses how robust terpenes profiles are important for marketing.

An introduction to the environmental and contamination impact course.

This video discusses the chemicals of cannabis: what happens, what is present and when is it present, what to harness, and what is waste.

This course discuss the most common components found in cannabis products.

This video discusses the primary methods of extraction. It discusses what components remain after extraction and how to get to the final product in the end.

This video discusses the pesticide considerations that extractors need to understand. This includes testing lab requirements, proper equipment, clean materials, heavy metal considerations, and microbiological considerations.

This video discusses spent material considerations and the items that may be left behind on the extracted plant material.

An introduction to the future of extraction.

This video discusses the best concentration processes for cannabis and all natural products. The lesson discusses the categories that make up B.E.S.T. or Botanical, Effective Concentration, Safety and Testing.

This video discusses the modes of concentration and how extraction and separation differ, and the physical properties that they require.

This video discusses technology needed when considering the extraction process, and what happens during a cycle.

This video talks about the reality of the extraction business along with the science, and how to make money, increase revenue, decrease cost, and optimize asset utilization.

This video discusses three significant changes that have happened in the cannabis industry since 2016: more companies, multiple products, and expansion.